Diagnostic merits of the Eosinophilic Esophagitis Diagnostic Panel from a single esophageal biopsy.

ABSTRACT:

Background

Eosinophilic esophagitis (EoE) is a histologically "patchy" disease with uneven eosinophil distribution along the esophagus, posing a dilemma for histologically analyzing endoscopic biopsy samples, especially when biopsy samples are limited to only the distal esophagus.

Objective

We investigated whether molecular mRNA profiling of a distal esophageal biopsy sample predicts eosinophilia in the proximal esophagus.

Methods

Esophageal biopsy samples (n = 507) from subjects with EoE were collected from multiple institutions, spanning adults and pediatric patients. Subjects were grouped on the basis of distinct distal (D) and proximal (P) eosinophil counts (D⁺P⁺, D⁺P^-, D^-P⁺, and D^-P

SUBMITTER: Min S 

PROVIDER: S-EPMC8821114 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature