Prenatal phthalate exposure in relation to placental corticotropin releasing hormone (pCRH) in the CANDLE cohort.

ABSTRACT:

Context

Phthalates may disrupt maternal-fetal-placental endocrine pathways, affecting pregnancy outcomes and child development. Placental corticotropin releasing hormone (pCRH) is critical for healthy pregnancy and child development, but understudied as a target of endocrine disruption.

Objective

To examine phthalate metabolite concentrations (as mixtures and individually) in relation to pCRH.

Design

Secondary data analysis from a prospective cohort study.

Setting

Prenatal clinics in Tennessee, USA.

Patients

1018 pregnant women (61.4% non-Hispanic Black, 32% non-Hispanic White, 6.6% other) participated in the CANDLE study and provided data. Inclusion criteria included: low-medical-risk singleton pregnancy, age 16-40, and gestational weeks 16-29.

Inter

SUBMITTER: Barrett ES 

PROVIDER: S-EPMC8821329 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature