Relationships between dopamine D2/3 receptor availability and social-environmental factors in humans.

ABSTRACT: Social factors are associated with psychiatric outcomes and brain function. Relationships between local population data obtained from Social Explorer analyses of the American Community Survey (2014-2018) and dopamine D_2/3 receptor (D_2/3R) availability were explored in this retrospective analysis of [¹¹C]PHNO positron emission tomography (PET) imaging data (n = 70). Larger local population size and lower percentage of the population with a bachelor's degree or higher were significantly associated with higher striatal D_2/3R availability, suggesting that living in a populous area with fewer educational resources may be accompanied by stressors with concomitant dopaminergic changes. Future prospective, collaborative studies are needed to better under

SUBMITTER: Calakos KC 

PROVIDER: S-EPMC8821418 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature