A Novel Point-of-Care Rapid Diagnostic Test for Screening Individuals for Antibody Deficiencies.

ABSTRACT:

Purpose

No rapid diagnostic test exists to screen individuals for primary antibody deficiencies (PAD) at or near the point of care. In settings at risk for polio where live oral polio vaccine is utilized, undiagnosed PAD patients and cases with delayed diagnosis constitute a potential reservoir for neurovirulent polioviruses, undermining polio eradication. This research aimed to develop a rapid screening test suited for use in resource-limited settings to identify individuals with low immunoglobulin G (IgG) levels, enabling early diagnosis and appropriate treatment.

Methods

Three prototype tests distinguishing low and normal IgG levels were evaluated with a blinded panel of serum/plasma specimens from 32 healthy controls and 86 primary immunodeficiency-confirmed patients wit

SUBMITTER: Israeli S 

PROVIDER: S-EPMC8821486 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature