Periodontal disease as a risk factor for sporadic colorectal cancer: results from COLDENT study.

ABSTRACT: Colorectal cancer remains the top leading cancer worldwide. Accumulating evidence suggests periodontal pathogens are involved in colorectal carcinogenesis, indicating the need for high-quality epidemiological evidence linking periodontal disease (PD) and colorectal cancer (CRC). Thus, we conducted the first population-based case-control study that was specifically designed to investigate the association between compromised oral health and sporadic CRC. A total of 348 incident cases of colon or rectal cancer, and 310 age and sex frequency-matched controls, from the Montreal island and Laval population participated in the study. Data were collected on PD and on several CRC risk factors using validated questionnaires. A life-course approach was used to document long-term history regarding lif

SUBMITTER: Idrissi Janati A 

PROVIDER: S-EPMC8821510 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature