Metabolic and Nutritional Disorders Following the Administration of Immune Checkpoint Inhibitors: A Pharmacovigilance Study.

ABSTRACT:

Background

Although several metabolic and nutritional disorders (MNDs) have been reported in the recipients of immune checkpoint inhibitors (ICIs), these events have not been fully captured and comprehensively characterized in real-world population.

Objectives

To provide complete metabolic and nutritional toxicity profiles after ICIs (single and combined) initiation through an integrated big database.

Methods

Reporting odds ratios (ROR) and information component (IC) based on statistical shrinkage transformation were utilized to perform disproportionality analysis using the US Food and Drug Administration Adverse Events Reporting System. Both ROR and IC were used to calculate disproportionality when compared with the whole database, but only ROR was used when comparis

SUBMITTER: Zhai Y 

PROVIDER: S-EPMC8821653 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature