Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain.

ABSTRACT: Postsynaptic NMDARs at spinal synapses are required for postsynaptic long-term potentiation and chronic pain. However, how presynaptic NMDARs (PreNMDARs) in spinal nociceptor terminals control presynaptic plasticity and pain hypersensitivity has remained unclear. Here we report that PreNMDARs in spinal nociceptor terminals modulate synaptic transmission in a nociceptive tone-dependent manner. PreNMDARs depresses presynaptic transmission in basal state, while paradoxically causing presynaptic potentiation upon injury. This state-dependent modulation is dependent on Ca²⁺ influx via PreNMDARs. Small conductance Ca²⁺-activated K⁺ (SK) channels are responsible for PreNMDARs-mediated synaptic depression. Rather, tissue inflammation induces PreNMDARs-PKG-I-depende

SUBMITTER: Xie RG 

PROVIDER: S-EPMC8821657 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature