Reconstituting the complete biosynthesis of D-lysergic acid in yeast.

ABSTRACT: The ergot alkaloids are a class of natural products known for their pharmacologically privileged molecular structure that are used in the treatment of neurological ailments, such as Parkinsonism and dementia. Their synthesis via chemical and biological routes are therefore of industrial relevance, but suffer from several challenges. Current chemical synthesis methods involve long, multi-step reactions with harsh conditions and are not enantioselective; biological methods utilizing ergot fungi, produce an assortment of products that complicate product recovery, and are susceptible to strain degradation. Reconstituting the ergot alkaloid pathway in a strain strongly amenable for liquid fermentation, could potentially resolve these issues. In this work, we report the production of the main er

SUBMITTER: Wong G 

PROVIDER: S-EPMC8821704 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature