Connectome-wide Functional Connectivity Abnormalities in Youth With Obsessive-Compulsive Symptoms.

ABSTRACT:

Background

Obsessive-compulsive symptomatology (OCS) is common in adolescence but usually does not meet the diagnostic threshold for obsessive-compulsive disorder. Nevertheless, both obsessive-compulsive disorder and subthreshold OCS are associated with increased likelihood of experiencing other serious psychiatric conditions, including depression and suicidal ideation. Unfortunately, there is limited information on the neurobiology of OCS.

Methods

Here, we undertook one of the first brain imaging studies of OCS in a large adolescent sample (analyzed n = 832) from the Philadelphia Neurodevelopmental Cohort. We investigated resting-state functional magnetic resonance imaging functional connectivity using complementary analytic approaches that focus on different neuroanatomica

SUBMITTER: Alexander-Bloch AF 

PROVIDER: S-EPMC8821731 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature