Extracellular vesicles derived from inflammatory-educated stem cells reverse brain inflammation-implication of miRNAs.

ABSTRACT: Inflammation plays a key role in the development of age-related diseases. In Alzheimer's disease, neuronal cell death is attributed to amyloidbeta oligomers that trigger microglial activation. Stem cells have shown promise as therapies for inflammatory diseases- because of their paracrine activity combined with their ability to respond to the inflammatory environment. However, the mechanisms underlying stem cell-promoted neurological recovery are poorly understood. To elucidate these mechanisms, we first primed stem cells with the secretome of lipopolysaccharide- or amyloidbeta-activated microglia. Then, we compared the immunomodulatory effects of extracellular vesicles (EVs) secreted from primed and non-primed stem cells. Our results demonstrate that EVs from primed cells are more effecti

SUBMITTER: Markoutsa E 

PROVIDER: S-EPMC8821927 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature