In silico Single-Cell Analysis of Steroid-Responsive Gene Targets in the Mammalian Cochlea.

ABSTRACT:

Background

Treatment of many types of hearing instability in humans, including sudden sensorineural hearing loss, Meniere's disease, and autoimmune inner ear disease, rely heavily on the utilization of corticosteroids delivered both by oral and transtympanic routes. Despite this use, there is heterogeneity in the response to treatment with corticosteroids in humans with these diseases. The mechanisms by which corticosteroids exert their effect and the cell types in which they exert their effects in the inner ear remain poorly characterized. In this study, we localize steroid-responsive genes to cochlear cell types using previously published transcriptome datasets from the mammalian cochlea.

Methods

Steroid-responsive genes were localized to specific cochlear cell types using

SUBMITTER: Nelson L 

PROVIDER: S-EPMC8821961 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature