Improved post-stroke spontaneous recovery by astrocytic extracellular vesicles.

ABSTRACT: Spontaneous recovery after a stroke accounts for a significant part of the neurological recovery in patients. However limited, the spontaneous recovery is mechanistically driven by axonal restorative processes for which several molecular cues have been previously described. We report the acceleration of spontaneous recovery in a preclinical model of ischemia/reperfusion in rats via a single intracerebroventricular administration of extracellular vesicles released from primary cortical astrocytes. We used magnetic resonance imaging and confocal and multiphoton microscopy to correlate the structural remodeling of the corpus callosum and striatocortical circuits with neurological performance during 21 days. We also evaluated the functionality of the corpus callosum by repetitive recordings of

SUBMITTER: Heras-Romero Y 

PROVIDER: S-EPMC8821969 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature