Molecular Characterization of Candida auris Isolates at a Major Tertiary Care Center in Lebanon.

ABSTRACT:

Background

The globally emerging Candida auris pathogens poses heavy burden to the healthcare system. Their molecular analyses assist in understanding their epidemiology, dissemination, treatment, and control. This study was warranted to describe the genomic features and drug resistance profiles using whole genome sequencing (WGS) among C. auris isolates from Lebanon.

Methods

A total of 28 C. auris clinical isolates, from different hospital units, were phenotypically identified by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) and tested for antifungal resistance using Vitek-2 system and E test. The complete genomes were determined by WGS using long reads sequencing (PacBio) to reveal the clade distribution and antif

SUBMITTER: Reslan L 

PROVIDER: S-EPMC8822126 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature