10-year longitudinal study of malaria in children: Insights into acquisition and maintenance of naturally acquired immunity.

ABSTRACT: Background: Studies of long-term malaria cohorts have provided essential insights into how Plasmodium falciparum interacts with humans, and influences the development of antimalarial immunity. Immunity to malaria is acquired gradually after multiple infections, some of which present with clinical symptoms. However, there is considerable variation in the number of clinical episodes experienced by children of the same age within the same cohort. Understanding this variation in clinical symptoms and how it relates to the development of naturally acquired immunity is crucial in identifying how and when some children stop experiencing further malaria episodes. Where variability in clinical episodes may result from different rates of acquisition of immunity, or from variable exposu

SUBMITTER: Addy JWG 

PROVIDER: S-EPMC8822141 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature