No Causal Association Between Coffee Consumption and Risk of Migraine: A Mendelian Randomization Study.

ABSTRACT: Background and Aims: Coffee consumption has been suggested to increase the risk of migraine. However, causality remains inconclusive. In the present study, we performed a two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between coffee consumption and migraine. Methods: We obtained nine single-nucleotide polymorphisms (SNPs) associated with coffee consumption at genome-wide significance (p < 5 × 10^-8) from a large genome-wide association study (GWAS) based on the UK Biobank study (included 375,833 individuals). Summary-level data for any migraine (AM) and its subtypes (migraine with aura (MA) and migraine without aura (MO)) were obtained from the largest available GWAS of migraine conducted by the International Headache

SUBMITTER: Chen H 

PROVIDER: S-EPMC8822146 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature