Silver(I)-Tazobactam Frameworks with Improved Antimicrobial Activity.

ABSTRACT: Tazobactam (TazoH) is a penicillinate sulfone β-lactamase inhibitor with negligible antimicrobial activity, commonly used with other antibiotics to provide an effective combination against many susceptible organisms expressing β-lactamases. Two novel Ag(I)-tazobactam frameworks ([Ag(I)-Tazo] and [Ag(I)-Tazo₂]) prepared by mechanochemistry are presented herein as alternative forms to improve the antimicrobial activity of tazobactam by exploring synergistic effects with silver, being the first crystal structures reported of tazobactam coordinating to a metal site. The topological analysis of the 3D ([Ag(I)-Tazo]) and 2D+1D ([Ag(I)-Tazo₂]) frameworks revealed underlying nets with the cbs (CrB self-dual) and decorated sql topologies, respectively. These nove

SUBMITTER: Ferreira DR 

PROVIDER: S-EPMC8822216 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature