Comparison of Efficacy of Anti-interleukin-17 in the Treatment of Psoriasis Between Caucasians and Asians: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Interleukin-17 (IL-17) monoclonal antibody drugs have been increasingly significant in the treatment of psoriasis, but it is not clear whether the efficacy is equivalent across ethnicities.

Objective

To explore the differences of short-term efficacy of IL-17 inhibitors between Caucasians and Asians.

Methods

The pooled log risk ratio (logRR) between the groups was estimated. The meta-regression analysis on the logRR was performed, with the proportion of Caucasian patients as the covariate. The subgroup analysis was performed by specific IL-17 inhibitors.

Results

Of the 1,569 potentially relevant studies, sixteen randomized controlled trials (RCTs) were included. For the Psoriasis Area and Severity Index 75 (PASI 75) response at week 12, the pooled log

SUBMITTER: Zhang D 

PROVIDER: S-EPMC8822240 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature