Sensitive Measures of Cognition in Mild Cognitive Impairment.

ABSTRACT:

Background

Sensitive measures of cognition are needed in preclinical and prodromal Alzheimer's disease (AD) to track cognitive change and evaluate potential interventions. Neurofibrillary tangle pathology in AD is first observed in Brodmann Area 35 (BA35), the medial portion of the perirhinal cortex. The importance of the perirhinal cortex for semantic memory may explain early impairments of semantics in preclinical AD. Additionally, our research has tied figurative language impairment to neurodegenerative disease.

Objective

We aim to identify tasks that are sensitive to cognitive impairment in individuals with mild cognitive impairment (MCI), and that are sensitive to atrophy in BA35.

Methods

Individuals with MCI and cognitively normal participants (CN) were tested o

SUBMITTER: Klooster N 

PROVIDER: S-EPMC8822438 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature