Genome-wide association study identifies candidate loci associated with chronic pain and postherpetic neuralgia.

ABSTRACT:

Background

Human twin studies and other studies have indicated that chronic pain has heritability that ranges from 30% to 70%. We aimed to identify potential genetic variants that contribute to the susceptibility to chronic pain and efficacy of administered drugs. We conducted genome-wide association studies (GWASs) using whole-genome genotyping arrays with more than 700,000 markers in 191 chronic pain patients and a subgroup of 89 patients with postherpetic neuralgia (PHN) in addition to 282 healthy control subjects in several genetic models, followed by additional gene-based and gene-set analyses of the same phenotypes. We also performed a GWAS for the efficacy of drugs for the treatment of pain.

Results

Although none of the single-nucleotide polymorphisms (SNPs) were foun

SUBMITTER: Nishizawa D 

PROVIDER: S-EPMC8822450 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature