Antibody bivalency improves antiviral efficacy by inhibiting virion release independently of Fc gamma receptors.

ABSTRACT: Across the animal kingdom, multivalency discriminates antibodies from all other immunoglobulin superfamily members. The evolutionary forces conserving multivalency above other structural hallmarks of antibodies remain, however, incompletely defined. Here, we engineer monovalent either Fc-competent or -deficient antibody formats to investigate mechanisms of protection of neutralizing antibodies (nAbs) and non-neutralizing antibodies (nnAbs) in virus-infected mice. Antibody bivalency enables the tethering of virions to the infected cell surface, inhibits the release of virions in cell culture, and suppresses viral loads in vivo independently of Fc gamma receptor (FcγR) interactions. In return, monovalent antibody formats either do not inhibit virion release and fail to protect in vivo or the

SUBMITTER: Sahin M 

PROVIDER: S-EPMC8822495 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature