Observed steric crowding at modest coverage requires a particular membrane-binding scheme or a complementary mechanism.

ABSTRACT: Membrane shape transitions, including fusion and fission, play an important role in many biological processes. It is therefore essential to understand mechanisms of "curvature generation," the mathematical quantification of membrane shape. Among the different mechanisms is the effect of steric pressure between proteins crowded on a surface. At a higher curvature, there is more space for the crowders and less steric pressure. Currently, the physical model of curvature induction by crowding views the proteins as being bound to the surface as a whole rather than to the underlying lipids. Here, we split the previously understood model into two pieces: first, the reduction in steric pressure due to reduced collisions between proteins, and second, the increased area available to the protein that

SUBMITTER: Sapp K 

PROVIDER: S-EPMC8822614 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature