Growth kinetics and power laws indicate distinct mechanisms of cell-cell interactions in the aggregation process.

ABSTRACT: Cellular aggregation is a complex process orchestrated by various kinds of interactions depending on the environment. Different interactions give rise to different pathways of cellular rearrangement and the development of specialized tissues. To distinguish the underlying mechanisms, in this theoretical work, we investigate the spontaneous emergence of tissue patterns from an ensemble of single cells on a substrate following three leading pathways of cell-cell interactions, namely, direct cell adhesion contacts, matrix-mediated mechanical interaction, and chemical signaling. Our analysis shows that the growth kinetics of the aggregation process are distinctly different for each pathway and bear the signature of the specific cell-cell interactions. Interestingly, we find that the average do

SUBMITTER: Mukhopadhyay D 

PROVIDER: S-EPMC8822615 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature