Genetic analysis of disease resilience of wean-to-finish pigs under a natural disease challenge model using reaction norms.

ABSTRACT:

Background

Disease resilience is the ability to maintain performance across environments with different disease challenge loads (CL). A reaction norm describes the phenotypes that a genotype can produce across a range of environments and can be implemented using random regression models. The objectives of this study were to: (1) develop measures of CL using growth rate and clinical disease data recorded under a natural polymicrobial disease challenge model; and (2) quantify genetic variation in disease resilience using reaction norm models.

Methods

Different CL were derived from contemporary group effect estimates for average daily gain (ADG) and clinical disease phenotypes, including medical treatment rate (TRT), mortality rate, and subjective health scores. Resulting CL we

SUBMITTER: Cheng J 

PROVIDER: S-EPMC8822643 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature