Genetic polymorphism of ADAM17 and decreased bilirubin levels are associated with allergic march in the Korean population.

ABSTRACT:

Background

The "allergic march" refers to changes in the frequency and intensity of allergic diseases with age. Classically, the allergic march begins with atopic dermatitis in infancy and leads to asthma and rhinitis as it continues. There are many factors that induce the allergic march; however, TNF-α may play an important role in inducing inflammation. Therefore, the therapeutic potential of TNF alpha-targeting agents is being considered for allergic march treatment.

Methods

We performed a correlation study to determine whether genetic polymorphisms of ADAM17 and clinical serum values between allergic and normal groups affect disease development by using the cohort data of the Korean genome epidemiologic research project. Gene association study was performed using PLINK v

SUBMITTER: Jung J 

PROVIDER: S-EPMC8822644 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature