Changes in intrathoracic pressure, not arterial pulsations, exert the greatest effect on tracer influx in the spinal cord.

ABSTRACT:

Background

Cerebrospinal fluid (CSF) circulation in the brain has garnered considerable attention in recent times. In contrast, there have been fewer studies focused on the spine, despite the expected importance of CSF circulation in disorders specific to the spine, including syringomyelia. The driving forces that regulate spinal CSF flow are not well defined and are likely to be different to the brain given the anatomical differences and proximity to the heart and lungs. The aims of this study were to determine the effects of heart rate, blood pressure and respiration on the distribution of CSF tracers in the spinal subarachnoid space, as well as into the spinal cord interstitium.

Methods

In Sprague Dawley rats, physiological parameters were manipulated such that the effect

SUBMITTER: Liu S 

PROVIDER: S-EPMC8822685 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature