Neurocognitive impact of Zika virus infection in adult rhesus macaques.

ABSTRACT:

Background

Zika virus (ZIKV) is a mosquito-transmitted flavivirus that affects many regions of the world. Infection, in utero, causes microcephaly and later developmental and neurologic impairments. The impact of ZIKV infection on neurocognition in adults has not been well described. The objective of the study was to assess the neurocognitive impact of ZIKV infection in adult rhesus macaques.

Methods

Neurocognitive assessments were performed using the Cambridge Neuropsychological Test Automated Battery (CANTAB) via a touch screen and modified Brinkman Board before and after subcutaneous ZIKV inoculation. Immune activation markers were measured in the blood and cerebral spinal fluid (CSF) by multiplex assay and flow cytometry.

Results

All animals (N = 8) had detectable

SUBMITTER: Hsu DC 

PROVIDER: S-EPMC8822695 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature