CNS endothelial derived extracellular vesicles are biomarkers of active disease in multiple sclerosis.

ABSTRACT:

Background

Multiple sclerosis (MS) is a complex, heterogenous disease characterized by inflammation, demyelination, and blood-brain barrier (BBB) permeability. Currently, active disease is determined by physician confirmed relapse or detection of contrast enhancing lesions via MRI indicative of BBB permeability. However, clinical confirmation of active disease can be cumbersome. As such, disease monitoring in MS could benefit from identification of an easily accessible biomarker of active disease. We believe extracellular vesicles (EV) isolated from plasma are excellent candidates to fulfill this need. Because of the critical role BBB permeability plays in MS pathogenesis and identification of active disease, we sought to identify EV originating from central nervous system (CNS) en

SUBMITTER: Mazzucco M 

PROVIDER: S-EPMC8822708 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature