Lifetime risk of cardiovascular-renal disease in type 2 diabetes: a population-based study in 473,399 individuals.

ABSTRACT:

Background

Cardiovascular and renal diseases (CVRD) are major causes of mortality in individuals with type 2 diabetes (T2D). Studies of lifetime risk have neither considered all CVRD together nor the relative contribution of major risk factors to combined disease burden.

Methods

In a population-based cohort study using national electronic health records, we studied 473,399 individuals with T2D in England 2007-2018. Lifetime risk of individual and combined major adverse renal cardiovascular events, MARCE (including CV death and CVRD: heart failure; chronic kidney disease; myocardial infarction; stroke or peripheral artery disease), were estimated, accounting for baseline CVRD status and competing risk of death. We calculated population attributable risk for individual CVRD co

SUBMITTER: Zhang R 

PROVIDER: S-EPMC8822817 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature