Prenatal inflammation causes obesity and abnormal lipid metabolism via impaired energy expenditure in male offspring.

ABSTRACT:

Introduction

Obesity has becoming a global health issue. Fetus exposed to adversity in the uterine are susceptible to unhealth stimulus in adulthood. Prenatal inflammation is related to poor neonatal outcomes like neurodevelopmental impairments and respiratory complications. Recent studies suggested prenatal lipopolysaccharide (LPS) exposure could result in metabolic disorders. Thus, we hypothesized that offspring exposed to prenatal inflammation could develop into metabolic disorder.

Methods

The pregnant C57BL/6J mice were intraperitoneally injected with 50 μg/kg LPS or saline only once at GD15. The male offspring were weighted weekly until sacrificed. Indirect calorimetry and body composition were both performed at 9 and 18 weeks old. At 20 weeks old, mice were fasted over

SUBMITTER: Ni M 

PROVIDER: S-EPMC8822840 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature