Development of chronic kidney disease influenced by serum urate and body mass index based on young-to-middle-aged Japanese men: a propensity score-matched cohort study.

ABSTRACT:

Objective

To investigate the association between serum uric acid (SUA) level and body mass index (BMI) on the development of chronic kidney disease (CKD) in working men aged 20-60 years.

Design

Retrospective cohort study.

Setting

Data from employees' annual health check-ups were collected from two companies in 2009 and 2014.

Participants

A total of 16 708 working men were recruited. We excluded participants with missing essential data (N=7801), who had basal estimated glomerular filtration rate (eGFR) <60.0 mL/min/1.73 m² and/or proteinuria (N=698) or with the absence of follow-up data (N=2).

Primary outcome

eGFR <60 mL/min/1.73 m² and/or proteinuria (≥1+) in 2014 (defined as incident CKD).

Results

The cut-off values of SUA f

SUBMITTER: Kuma A 

PROVIDER: S-EPMC8823083 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature