Impact of human immunodeficiency virus status on laryngeal cancer survival and locoregional control.

ABSTRACT:

Objectives

To compare long-term outcomes of laryngeal cancer (LC) in people living with HIV (PLWH) versus uninfected individuals and determine how clinical and viral factors-such as demographics, cancer stage, HIV viral load, and CD4 nadir-contribute to these outcomes.

Methods

This was a retrospective case-control study of 749 patients seen for LC at a single tertiary care center between 2003 and 2017. Of these, 22 had HIV at the time of LC diagnosis, and they were matched in a 1:4 ratio to uninfected controls based on sex, presence of smoking history, and age at cancer diagnosis. Kaplan-Meier survival curves and Cox proportional hazards models were constructed to identify overall and disease-free survival differences based on HIV status, as well as other clinical and viral

SUBMITTER: Weinreb SF 

PROVIDER: S-EPMC8823145 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature