Mathematical Model of Macromolecular Drug Transport in a Partially Liquefied Vitreous Humor.

ABSTRACT: The purpose of this study is to investigate the effect of partial liquefaction (due to ageing) of the vitreous humor on the transport of ocular drugs. In our model, the gel part of the vitreous is treated as a Darcy-type porous medium. A spherical region within the porous part of vitreous is in a liquid state which, for computational purposes, is also treated as a porous medium but with a much higher permeability. Using the finite element method, a time-dependent, three-dimensional model has been developed to computationally simulate (using the Petrov-Galerkin method) the transport of intravitreally injected macromolecules where both convection and diffusion are present. From a fluid physics and transport phenomena perspective, the results show many interesting features. For pressure-drive

SUBMITTER: Khoobyar A 

PROVIDER: S-EPMC8823200 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature