Clinical use of shear-wave elastography for detecting liver fibrosis in children and adolescents with cystic fibrosis.

ABSTRACT:

Background

Complications from liver cirrhosis are a leading cause of death in children with cystic fibrosis. Identifying children at risk for developing liver cirrhosis and halting its progression are critical to reducing liver-associated mortality.

Objective

Quantitative US imaging, such as shear-wave elastography (SWE), might improve the detection of liver fibrosis in children with cystic fibrosis (CF) over gray-scale US alone. We incorporated SWE in our pediatric CF liver disease screening program and evaluated its performance using magnetic resonance (MR) elastography.

Materials and methods

Ninety-four children and adolescents with CF underwent 178 SWE exams, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT) and pla

SUBMITTER: Levitte S 

PROVIDER: S-EPMC8823212 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature