Residential PM_2.5 exposure and the nasal methylome in children.

ABSTRACT:

Rationale

PM_2.5-induced adverse effects on respiratory health may be driven by epigenetic modifications in airway cells. The potential impact of exposure duration on epigenetic alterations in the airways is not yet known.

Objectives

We aimed to study associations of fine particulate matter PM_2.5 exposure with DNA methylation in nasal cells.

Methods

We conducted nasal epigenome-wide association analyses within 503 children from Project Viva (mean age 12.9 y), and examined various exposure durations (1-day, 1-week, 1-month, 3-months and 1-year) prior to nasal sampling. We used residential addresses to estimate average daily PM_2.5 at 1 km resolution. We collected nasal swabs from the anterior nares and measured DNA methylation (DNAm) usin

SUBMITTER: Sordillo JE 

PROVIDER: S-EPMC8823376 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature