Inhibitory effects of Nigella sativa seed oil on the testosterone-induced benign prostatic hyperplasia in rats.

ABSTRACT:

Background

Benign prostatic hyperplasia (BPH) is the most prevalent disease of the prostate in elderly men. Since Nigella sativa has been reported to show various pharmacological effects, this study was conducted to examine the effect of N. sativa seed oil on experimental BPH.

Methods

The oil was extracted using the cold-pressing method. Fifty rats were divided into five groups of 10 each as follows: Group 1 orally (p.o.) received normal saline; groups 2-5 were castrated and subcutaneously received 5 mg/kg testosterone propionate for four weeks. Group 2, namely, BPH model, underwent no further treatment, Groups 3 and 4 were treated with 400 mg/kg and 800 mg/kg N. sativa seed oil, Group 5 received finasteride (0.5 mg/kg, p.o.) for 28 days. All grou

SUBMITTER: Sadeghimanesh A 

PROVIDER: S-EPMC8823465 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature