Association study of polymorphism in Thrombomodulin gene [rs1042579] with cardiovascular disease.

ABSTRACT:

Background and aim

Thrombomodulin (THBD) gene plays an important role in activation and control of protein C. Regulation protein C levels as an important risk factor for cardiovascular disease. Mutations in this gene can affect Thrombomodulin levels. In this study, we aimed to investigate the role of single nucleotide polymorphism (SNP) in rs1042579 THBD gene in patients with cardiovascular disease.

Methods

The samples of this case-control study consisted of 105 Iranian patients with cardiovascular disease and 95 healthy controls who enrolled from March 2017 to December 2018 in this study.  Demographic data, medical history, and para-clinical were measured, and Sanger sequencing was used for allelic discrimination. Control samples were identified and then selected for genoty

SUBMITTER: Khosravi E 

PROVIDER: S-EPMC8823559 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature