Construction of the Enterococcal Strain Expressing Immunogenic Fragment of SARS-Cov-2 Virus.

ABSTRACT: Contemporary SARS-Cov-2 pandemic, besides its dramatic global influence on the human race including health care systems, economies, and political decisions, opened a window for the global experiment with human vaccination employing novel injectable vaccines providing predominantly specific IgG response with little knowledge of their impact on the mucosal immunity. However, it is widely accepted that protection against the pathogens at the gates of the infection - on mucosal surfaces-predominantly rely on an IgA response. Some genetically modified bacteria, including probiotics, represent attractive vehicles for oral or nasal mucosal delivery of therapeutic molecules. Probiotic-based vaccines for mucous membranes are easy to produce in large quantities; they have low cost, provide quite a l

SUBMITTER: Suvorov A 

PROVIDER: S-EPMC8823703 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature