Use and Outcomes of Induction Therapy in Well-Matched Kidney Transplant Recipients.

ABSTRACT:

Background and objectives

The optimal induction treatment in low-immune risk kidney transplant recipients is uncertain. We therefore investigated the use and outcomes of induction immunosuppression in a low-risk cohort of patients who were well matched with their donor at HLA-A, -B, -DR, -DQB1 on the basis of serologic typing.

Design, setting, participants, & measurements

Our study was an observational study of first adult kidney-only transplant recipients in the United States recorded by the Organ Procurement and Transplant Network.

Results

Among 2976 recipients, 57% were treated with T cell-depleting antibodies, 28% were treated with an IL-2 receptor antagonist, and 15% were treated without induction. There was no difference in allograft survival, death-censored gra

SUBMITTER: Evans RDR 

PROVIDER: S-EPMC8823946 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature