Antigenicity and adhesiveness of a Plasmodium vivax VIR-E protein from Brazilian isolates.

ABSTRACT:

Background

Plasmodium vivax, the major cause of malaria in Latin America, has a large subtelomeric multigene family called vir. In the P. vivax genome, about 20% of its sequences are vir genes. Vir antigens are grouped in subfamilies according to their sequence similarities and have been shown to have distinct roles and subcellular locations. However, little is known about vir subfamilies, especially when comes to their functions.

Objective

To evaluate the diversity, antigenicity, and adhesiveness of Plasmodium vivax VIR-E.

Methods

Vir-E genes were amplified from six P. vivax isolates from Manaus, North of Brazil. The presence of naturally acquired antibodies to recombinant PvBrVIR-E and PvAMA-1 was evaluated by ELISA. Binding capacity of recombinant PvBrVIR-E was ass

SUBMITTER: Schappo AP 

PROVIDER: S-EPMC8824159 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature