Biogeography and genetic diversity of clinical isolates of Burkholderia pseudomallei in Sri Lanka.

ABSTRACT:

Background

Melioidosis is a potentially fatal infectious disease caused by Burkholderia pseudomallei and the disease is endemic in Southeast Asia and Northern Australia. It has been confirmed as endemic in Sri Lanka. Genomic epidemiology of B. pseudomallei in Sri Lanka is largely unexplored. This study aims to determine the biogeography and genetic diversity of clinical isolates of B. pseudomallei and the phylogenetic and evolutionary relationship of Sri Lankan sequence types (STs) to those found in other endemic regions of Southeast Asia and Oceania.

Methods

The distribution of variably present genetic markers [Burkholderia intracellular motility A (bimA) gene variants bimABP/bimABM, filamentous hemagglutinin 3 (fhaB3), Yersinia-like fimbrial (YLF) and B. thailandensis-like

SUBMITTER: Jayasinghearachchi HS 

PROVIDER: S-EPMC8824316 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature