Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing.

ABSTRACT: Chronic inflammation is often associated with the development of tissue fibrosis, but how mesenchymal cell responses dictate pathological fibrosis versus resolution and healing remains unclear. Defining stromal heterogeneity and identifying molecular circuits driving extracellular matrix deposition and remodeling stands to illuminate the relationship between inflammation, fibrosis, and healing. We performed single-cell RNA-sequencing of colon-derived stromal cells and identified distinct classes of fibroblasts with gene signatures that are differentially regulated by chronic inflammation, including IL-11-producing inflammatory fibroblasts. We further identify a transcriptional program associated with trans-differentiation of mucosa-associated fibroblasts and define a functional gene signat

SUBMITTER: Jasso GJ 

PROVIDER: S-EPMC8824371 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature