Towards sex-specific osteoarthritis risk models: evaluation of risk factors for knee osteoarthritis in males and females.

ABSTRACT:

Objectives

The aim of this study was to identify sex-specific prevalence and strength of risk factors for the incidence of radiographic knee OA (incRKOA).

Methods

Our study population consisted of 10 958 Rotterdam Study participants free of knee OA in one or both knees at baseline. One thousand and sixty-four participants developed RKOA after a median follow-up time of 9.6 years. We estimated the association between each available risk factor and incRKOA using sex stratified multivariate regression models with generalized estimating equations. Subsequently, we statistically tested sex differences between risk estimates and calculated the population attributable fractions (PAFs) for modifiable risk factors.

Results

The prevalence of the investigated risk factors was, i

SUBMITTER: Szilagyi IA 

PROVIDER: S-EPMC8824415 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature