Nonparametric Parameters of 24-Hour Rest-Activity Rhythms and Long-Term Cognitive Decline and Incident Cognitive Impairment in Older Men.

ABSTRACT: Altered 24-hour rest-activity rhythms may be associated with cognitive impairment in older adults, but evidence from prospective studies is limited. Nonparametric methods were used to assess actigraphy-based activity patterns in 2 496 older men. Incident cognitive impairment was assessed 4 times over 12 years using the Modified Mini-Mental State Examination (3MS) and Trails B tests, self-reported medication use, and clinical diagnosis. The highest quartile (vs the lowest) of intradaily variability and the lowest quartiles (vs the highest) of interdaily stability and relative amplitude were associated with incident cognitive impairment (hazard ratio [95% confidence interval]: 1.82 [1.31-2.53], 1.36 [0.99-1.86], and 1.85 [1.33-2.56], respectively). A larger increase in intradaily variability

SUBMITTER: Xiao Q 

PROVIDER: S-EPMC8824593 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature