Beyond Antoni: A Surgeon's Guide to the Vestibular Schwannoma Microenvironment.

ABSTRACT: Introduction  Vestibular schwannomas (VS) are histologically benign tumors arising from cranial nerve VIII. Far from a homogenous proliferation of Schwann cells, mounting evidence has highlighted the complex nature of the inflammatory microenvironment in these tumors. Methods  A review of the literature pertaining to inflammation, inflammatory molecular pathways, and immune-related therapeutic targets in VS was performed. Relevant studies published up to June 2020 were identified based on a literature search in the PubMed and MEDLINE databases and the findings were synthesized into a concise narrative review of the topic. Results  The VS microenvironment is characterized by a dense infiltrate of inflammatory cells, particularly macrophages. Significantly higher levels

SUBMITTER: Hannan CJ 

PROVIDER: S-EPMC8824628 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature