Advancement of PI3 Kinase Inhibitor Combination Therapies for PI3K-Aberrant Chordoma.

ABSTRACT: Objectives  Targeted inhibitors of the PI3 kinase (PI3K) pathway have shown promising but incomplete antitumor activity in preclinical chordoma models. The aim of this study is to advance methodology for a high-throughput drug screen using chordoma models to identify new combination therapies for chordoma. Study Design  Present work is an in vitro study. Setting  The study conducted at an academic research laboratory. Materials and Methods  An in vitro study on automated high-throughput screening of chordoma cells was performed using a library of 1,406 drugs as both mono- and combination therapies with PI3K inhibitors. Combination indices were determined for dual therapies and synergistic outliers were identified as potential therapeutic agents. T (brachy

SUBMITTER: Heft Neal ME 

PROVIDER: S-EPMC8824629 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature