Role of Fasciola hepatica Small RNAs in the Interaction With the Mammalian Host.

ABSTRACT: MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression being involved in many different biological processes and play a key role in developmental timing. Additionally, recent studies have shown that miRNAs released from parasites are capable of regulating the expression of host genes. In the present work, we studied the expression patterns of ncRNAs of various intra-mammalian life-cycle stages of the liver fluke, Fasciola hepatica, as well as those packaged into extracellular vesicles and shed by the adult fluke. The miRNA expression profile of the intra-mammalian stages shows important variations, despite a set of predominant miRNAs that are highly expressed across all stages. No substantial variations in miRNA expression between dormant and activated m

SUBMITTER: Fontenla S 

PROVIDER: S-EPMC8824774 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature