A functional TGFB1 polymorphism in the donor associates with long-term graft survival after kidney transplantation.

ABSTRACT:

Background

Improvement of long-term outcomes in kidney transplantation remains one of the most pressing challenges, yet drug development is stagnating. Human genetics offers an opportunity for much-needed target validation in transplantation. Conflicting data exist about the effect of transforming growth factor-beta 1 (TGF-β1) on kidney transplant survival, since TGF-β1 has pro-fibrotic and protective effects. We investigated the impact of a recently discovered functional TGFB1 polymorphism on kidney graft survival.

Methods

We performed an observational cohort study analysing recipient and donor DNA in 1271 kidney transplant pairs from the University Medical Centre Groningen in The Netherlands, and associated a low-producing TGFB1 polymorphism (rs1800472-C > T)

SUBMITTER: Poppelaars F 

PROVIDER: S-EPMC8824786 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature