Podocyturia in Fabry disease: a 10-year follow-up.

ABSTRACT:

Background

Fabry disease (FD) is a rare X-linked disorder of sphingolipid metabolism that results in chronic proteinuric nephropathy. Podocytes are one of the most affected renal cells and play an important role in the development and progression of kidney disease. Detached podocytes found in urine (podocyturia) are considered as a non-invasive early marker of kidney injury; however, the dynamics of podocyte loss remains unknown.

Methods

In this 10-year follow-up study, podocyturia and other renal clinical data were evaluated in 39 patients with FD. From 2009 to 2019, podocyturia was assessed in 566 fresh urine samples from 13 male and 26 female FD patients using immunocytochemical detection of podocalyxin.

Results

Podocyturia (number of podocytes per 100 mL of urine)

SUBMITTER: Vujkovac B 

PROVIDER: S-EPMC8824799 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature