Plasma neutrophil gelatinase-associated lipocalin and kidney graft outcome.

ABSTRACT:

Background

Plasma neutrophil gelatinase-associated lipocalin (pNGAL) has been investigated extensively in acute kidney injury. This study investigated its pathophysiological significance and utility as marker for graft failure and mortality in stable kidney transplant recipients (KTR).

Methods

Baseline pNGAL was measured in 698 KTR (58% male, age 53 ± 13 years, estimated glomerular filtration rate 52.4 ± 20.4 mL/min/1.73 m²) at median 5.4 (interquartile range 1.8-12.0) years after transplantation, enrolled in the prospective TransplantLines Food and Nutrition Biobank and Cohort Study.

Results

pNGAL concentrations were higher in males, younger patients, patients with a deceased-donor kidney and higher serum creatinine. Independent of these, pNGAL was positiv

SUBMITTER: Kremer D 

PROVIDER: S-EPMC8824800 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature