Prefrontal and striatal dopamine D₂/D₃ receptors correlate with fMRI BOLD activation during stopping.

ABSTRACT: D₂-like dopamine receptors in animals and humans have been shown to be linked to impulsive behaviors that are highly relevant for several psychiatric disorders. Here, we investigate the relationship between the fronto-striatal D₂/D₃ dopamine receptor availability and response inhibition in a selected population of healthy OPRM1 G-allele carriers. Twenty-two participants successively underwent blood-oxygen level dependent functional magnetic resonance imaging (fMRI) while performing a stop-signal task and a separate positron emission tomography (PET) scan. Striatal and extrastriatal D₂/D₃ dopamine receptor availability was measured using the radiotracer [¹⁸F]fallypride. Caudate D₂/D₃ dopamine receptor av

SUBMITTER: Pfeifer P 

PROVIDER: S-EPMC8825403 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature